Open Access
Table 4
“Cutaneous comfort” in vivo study results on instrumental measurement, clinical scoring color and biomarkers parameters.
| TOC | Placebo | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Part | Evaluation | D0 (m±σ) | D28 (m±σ) | %D28/D0 | p value / D28 vs D0 |
D0 (m±σ) | D28 (m±σ) | %D28/D0 | p value / D28 vs D0 | TOC vs Placebo p value |
|
| Instrumental Measurement | Hydration (a.u.) | 48.73±16.97 | 60.97±13.27 | 25.1% | 0.000 | 45.34±15.74 | 56.31±13.93 | 24.2% | 0.000 | 0.787 | |
| TEWL (g/m2/h) | 13.6±2.38 | 11.9±2.34 | -12.5% | 0.000 | 12.78±2.83 | 11.68±2.5 | -8.7% | 0.000 | 0.046 | ||
| Clinical Scoring | Desquamation / Scaling | 0.88±1.45 | 0.38±0.92 | -57.1% | 0.016 | 1.5±1.87 | 0.63±0.92 | -58.3% | 0.002 | 0.402 | |
| Redness | 3.54±1.56 | 2.38±1.56 | -32.9% | 0.000 | 3.88±1.62 | 3±1.59 | -22.6% | 0.000 | 0.309 | ||
| Roughness | 2.08±2.34 | 1.21±1.64 | -42% | 0.001 | 2.58±1.95 | 1.71±1.71 | -33.9% | 0.002 | 0.689 | ||
| Overall dryness | 3.96±2.33 | 2.04±2.24 | -48.4% | 0.000 | 4.79±2.06 | 2.92±2 | -39.1% | 0.000 | 0.932 | ||
| Cutaneous discomfort | 6.08±1.86 | 2.38±2.75 | -61% | 0.000 | 6.38±1.56 | 2.67±2.6 | -58.2% | 0.000 | 1.000 | ||
| Color | L* | 61.24±2.29 | 64.35±2.14 | 5.1% | 0.000 | 60.94±3.11 | 64.52±1.96 | 5.9% | 0.000 | 0.258 | |
| a* | 13.04±2.69 | 10.14±1.91 | -22.2% | 0.000 | 13.21±2.66 | 10.07±2.33 | -23.8% | 0.000 | 0.710 | ||
| Biomarkers | IL1-α | 858.45±523.56 | 496.4±316.72 | -42.2% | 0.000 | 965.5±567.2 | 925.45±534.54 | -4.1% | 0.087 | 0.000 | |
| Cortisol | 423.89±257.23 | 317.2±172.78 | -25.2% | 0.002 | 465.81±300.69 | 393.29±288.19 | -15.6% | 0.004 | 0.737 | ||
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