Histological analysis of explant model (hematoxylin, eosin stain); (b) Quantification of stratum corneum thickness; (c) Analysis of Lucifer Yellow fluorescent dye diffusion through the explants (yellow: Lucifer Yellow dye, blue: DAPI; (d) Quantification of Lucifer Yellow dye penetration. $$$ p < 0.001 vs control; *** p < 0.001 vs stress or placebo; one Way ANOVA followed by Tukey’s or Dunnett’s test